22/12/2009

Adapalene 0.1% and benzoyl peroxide 2.5%: a novel combination for treatment of acne vulgaris

  Tan JK.
 Skin Therapy Lett. 2009 Jul-Aug;14(6):4-5
Department of Medicine, University of Western Ontario, London, ON, Canada.
Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (Epiduo, Galderma) and was approved by the US FDA in December 2008 for the treatment of acne. The superior efficacy of this combination was demonstrated in 2 large randomized controlled trials. This paper reviews the evidence for efficacy and tolerability of the combination of the retinoid adapalene 0.1% and BPO 2.5%, a once-daily gel formulation for the treatment of acne.
PMID: 19609474